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Nandralone Decanoate & TRT Combination Effects on Muscle Mass Increases by NIH/PubMed

Updated: Nov 23, 2021

Below is a PubMed study we have cited that illustrates the double blind placebo controlled effects on body mass increases when using (ND) Nandrolone Decanoate injections. This medication is an androgenic anabolic steroid used off label by performance clinics and on label by many physicians worldwide for traditional uses.

(UPDATE: 10/13/2021) - Week 7-8 has shown high validity and success with our patient test group. No side effects have been reported as of today. No interaction complications have been observed with Testosterone Cypionate or Enanthate co-occurring injections. No injection site pain, swelling, bruising, or cystic buildup has been reported outside of the typical slight pain from the hypodermic needle insertion. Patient group 1 that is injecting 0.1mL (IM) before every workout have reported less fatigue in later stages of their workout, as well as a perceived increase in recovery time both into-set and 24 hour post. Due to the short half life of ND the patient group that is administering ND 1-3 hours before each workout has reported higher success in regards to fatigue, lean muscle mass, weight tolerance, and muscle failure. Follow up SHBG + endocrine labs have been scheduled, stay tuned.

(UPDATE: 8/22/21) - MedClub® is currently undergoing our own 8 week study, please stay tuned to this blog for the updates. We will post the before and after effects of measurement, testosterone levels, sex-hormone binding globulin, albumin, estradiol, and physical body metrics.
UPDATE 11/23/21 - MedClub® has recorded a 40% rate of AAS related "androgenic" side effect cascades with the current patient group. These side effects include acne on chest/back, mostly non-cystic, as well as some hair loss. This ratio was higher in patients taking Nandrolone/Testosterone Cypionate in a pre-mixed compound versus the patients taking 0.2ml of Nandrolone multiple times per week. This leads us to believe we will see fluctuations of FSH and SHBG in this patient group.

How is this medication administered?

This medication is typically taken in dosages of 0.5mL (100mg) intramuscularly every 7 days. This dosage can differ based on the provider or individual. For intramuscular injection instructions see our video below.

Can this medication be combined?

We commonly see this medication combined with Testosterone Replacement Therapy regiments, although it is not usually used long term the way TRT can be. This medication cycle usually lasts about 8 weeks, and a break of 30-60 days is usually taken in between to preserve the effectiveness and maximize gains.

The Work

this medication, like most androgenic anabolic steroids does not produce muscle mass, bone density, or any other physical charicteristic without hard work. If you think you can sit on the couch and shred, think again. This study was performed on bodybuilders in multiple age groups, with an 8 week Big & Lean style workout regiment. At our clinic we can provide our clients with the exercise regiment of their choice, this is very important because as most people have discovered it is easier to pack on the muscle, than lose the fat. The best course of action is to pair the exercise, diet, supplements, and medications so they work symbiotically towards the same goal. If adding lean muscle mass is your goal, and your exercise regiment consists of cardio plus incremental weight lifting then you should have good results with Nandrolone Decanoate injections. This being said, the diet plays a very important role here, a diet of lean meat, vegetables, and protein is best. Stay away from whey proteins if possible, as they can add bloating and water weight that is not usually seen with paleo, vegan, or nut based proteins. Dairy, carbs, and empty calories should be removed from the diet. There is a reason why we put this paragraph under "The Work" section, because controlling what you eat takes WORK.

Risk Factors

when taking anabolic steroids especially androgenic ones it is important to have your provider check your prostate specific antigen (PSA) levels which are related to prostate cancer risks.


Introduction: The use of androgenic-anabolic steroids (AAS) among bodybuilders to increase muscle mass is widespread. Nandrolone decanoate (ND) is one of the most popular off-label AAS, although the effects on body composition are equivocal. Therefore, the purpose of this study was to determine the effect of ND on body composition in male bodybuilders, with special reference to muscle mass alterations.

Methods: Using a randomized "double-blind" "placebo-controlled" design, 16 experienced male bodybuilders (age: 19-44 yr) either received ND (200 mg.wk(-1), intramuscularly) or placebo for 8 wk. Body composition was assessed using the four-component model, combining results from underwater weighing, dual-energy x-ray absorptiometry (DXA), and deuterium dilution. Total bone mineral content and density were measured using DXA. Water compartments (extracellular water [ECW] and intracellular water [ICW]) were determined using deuterium dilution and bromide dilution.

Results: ND administration resulted in significant increments of body mass (+2.2 kg), fat-free mass (FFM: +2.6 kg), and total body water (+1.4 kg). No significant changes in fat mass, percentage fat, ECW, ICW, ECW/ICW ratio, hydration of the FFM, and on bone mineral measurements were observed.

Conclusions: The results show that the administration of 200 mg.wk(-1) of ND

(intramuscularly) for 8 wk significantly increased body mass and FFM, whereas fat mass, bone mineral content, bone mineral density, and the hydration of the FFM remained unaffected. These data indicate that the changes can be attributed to an increase of muscle mass.



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