• Z. Wilson

BPC-157 (Body Protection Compound - Bepecin)

BPC-157 (Body Protection Compound or Bepecin) is a pentadecapeptide made up of 15 amino acids that was discovered in human gastric juice. Experimentally, it has been demonstrated to accelerate the healing of injuries and wounds, including gastric ulcers, tendons, ligaments and bones. BPC-157 activates the proteinic FAK-paxillin pathway, induces F-actin formation in fibroblasts and increases the probability of cell survival during oxidative stress. BPC-157 is currently in phase II clinical trials for the treatment of IBD.





Typical Administration:


ORAL: 250-500 mcg by mouth daily in 1-2 divided doses

SUBQ: 250-500mcg subcutaneously once daily

INTRAMUSCULAR: 250-500mcg as close to the site of injury as possible QD-BID


SUBLINGUAL: 200-500 mcg between cheek and gum daily in 1-2 divided doses







Benefits:

BPC-157 is commonly used to repair tendons, ligaments, muscles, ulcers, & organ damage. Commonly prescribed with anti-inflammatories. The current research suggests Bepecin influences multiple growth factors commonly involved in angiogenesis (production of blood vessels, platelets) as well as other factors involved in regeneration following damage. It is commonly used by athletes to heal faster following an injury. Our first hand experience with this peptide has been daily good, showing 50-100% faster healing after injury. The current research has only been studied on rat populations, and much more is necessary to determine the exact methods of action pertaining to this peptide. BPC 157 may serve as a novel mediator of Robert’s cytoprotection, involved in maintaining of GI mucosa integrity, with no toxic effect. BPC 157 was successful in the therapy of GI tract, periodontitis, liver and pancreas lesions, and in the healing of various tissues and wounds. Stimulated Egr-1 gene, NAB2, FAK-paxillin and JAK-2 pathways are hitherto implicated.





Risks:

Unfortunately due to the limited research available only anecdotal evidence has suggested the low risk profile. This peptide is synthetically derived, and only mimics its organic counterpart. For this reason it may be banned in certain areas, or by sporting organizations.






Absorption:

Very little is known about the true absorption ratio of this peptide. Peptides in general are typically not well absorbed orally so the usual administration of this peptide is subcutaneous injection, or intramuscular depending on the dosage and reconstitution. Our pharmacists have very strict potency testing guidelines that they follow to make sure each vial produced adheres to a good measurement of accuracy. This being said, a sublingual may not prove as effective as an injectable of the same dosage.









Research Credits:

NCBI

Kamal Patel


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