BPC-157 (Body Protection Compound - Bepecin)
Updated: Mar 31, 2022
BPC-157 (Body Protection Compound or Bepecin) is a pentadecapeptide made up of 15 amino acids that was discovered in human gastric juice. Experimentally, it has been demonstrated to accelerate the healing of injuries and wounds, including gastric ulcers, tendons, ligaments and bones. BPC-157 activates the proteinic FAK-paxillin pathway, induces F-actin formation in fibroblasts and increases the probability of cell survival during oxidative stress. BPC-157 is currently in phase II clinical trials for the treatment of IBD.
Our BPC157 Experience: (Tendon/Ligament Repair)
We have been utilizing BPC-157 injections at our clinic for the past year and have been impressed with the efficacy overall. The safety profile seems good, we have not had any allergic reactions so far. The injections seem to be the most potent when including the absorption ratios into the equation. We inject 200-300mcg via subcutaneous injection as close to the site of injury as possible. We have found that the patients who address the injuries (ligament/tendon/muscle tears) as early as possible see the best recovery mitigation. We recently treated an (IT) tear in Dr. Jenn's left knee with Platelet Rich Plasma, allowed the inflammation response to occur over 7 days, then started BPC-157 twice daily immediately after with great results. An injury that would have taken multiple months to heal, ended up healing in less than 1 month. Tendon ends start to die quickly in post tear situations so treatment has to be done as soon as possible. BPC-157 has not been shown helpful when healing fully torn ligaments/tendons, but aids the recovery time after surgical intervention substantially. This also leads us to believe that this peptide could really benefit people undergoing physical therapy, or in the recovery phase of certain injuries. Currently it is concentrated in the athletic community, and access is somewhat limited, but we are making it available at our clinic at an affordable cost to any patients who qualify. We highly recommend the use of PRP before starting the BPC, as this combination/timeline of care has yielded the most promising results.
Typical Administration:
ORAL: 250-500 mcg by mouth daily in 1-2 divided doses
SUBQ: 250-500mcg subcutaneously once-twice daily
INTRAMUSCULAR: 250-500mcg as close to the site of injury as possible QD-BID
SUBLINGUAL: 200-500 mcg between cheek and gum daily in 1-2 divided doses
Benefits of BPC-157 Peptide:
BPC-157 is commonly used to repair tendons, ligaments, muscles, ulcers, & organ damage. Commonly prescribed with anti-inflammatories. The current research suggests Bepecin influences multiple growth factors commonly involved in angiogenesis (production of blood vessels, platelets) as well as other factors involved in regeneration following damage. It is commonly used by athletes to heal faster following an injury. Our first hand experience with this peptide has been daily good, showing 50-100% faster healing after injury. The current research has only been studied on rat populations, and much more is necessary to determine the exact methods of action pertaining to this peptide. BPC 157 may serve as a novel mediator of Robert’s cytoprotection, involved in maintaining of GI mucosa integrity, with no toxic effect. BPC 157 was successful in the therapy of GI tract, periodontitis, liver and pancreas lesions, and in the healing of various tissues and wounds. Stimulated Egr-1 gene, NAB2, FAK-paxillin and JAK-2 pathways are hitherto implicated.
Risks:
Unfortunately due to the limited research available only anecdotal evidence has suggested the low risk profile. This peptide is synthetically derived, and only mimics its organic counterpart. For this reason it may be banned in certain areas, or by sporting organizations.
Combining BPC-157 with other therapies or medications
We typically always start with a diagnosis at our clinic, and then assess the success ratio for each patient. This gives us a clear path as to which therapies will benefit them most, and also allows us to plot a timeline based on their lifestyle. For example someone who is very active and suffers a ligament tear will usually benefit most from an initial round of PRP (Platelet Rich Plasma) as soon as possible after the initial injury. Then we will allow the PRP some time to work (Usually a few weeks) before starting them on a course of BPC-157 injections. We will also utilize low dose Oxandralone orally around week 3 or 4 to help the patient maintain muscle mass and stop any atrophy from occurring. This combination is paired with a nutrient dense diet, fluids, electrolytes, and Ligaplex supplementation to make sure the body has more than it needs to undergo this process. The body is an amazing organism, able to assess, process, and restore damaged cells all on its own. What we are trying to do is simply study which parts are needed to do each individual task, and increase their effectiveness to give our patients a functional advantage.
Absorption:
Very little is known about the true absorption ratio of this peptide. Peptides in general are typically not well absorbed orally so the usual administration of this peptide is subcutaneous injection, or intramuscular depending on the dosage and reconstitution. Our pharmacists have very strict potency testing guidelines that they follow to make sure each vial produced adheres to a good measurement of accuracy. This being said, a sublingual may not prove as effective as an injectable of the same dosage.
How to start BPC-157 Therapy With Us
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Research Credits:
Jennifer Guthrie M.D.